Genitourinary Cancer MCQ : Multiple Choice Questions and Answers

Question 1 : The gene responsible for von Hippel-Lindau disease is found on:

a) chromosome 3p
b) chromosome 3q
c) chromosome 5p
d) chromosome 5q

Answer : chromosome 3p

Question 2 : Carriers of BAP1 mutations are at risk for :

a) Uveal and cutaneous melanoma
b) Malignant mesothelioma
c) Clear cell RCC
d) All of the above

Answer :  all of the above

Question 3 :  Hereditary papillary renal cancer syndrome is an autosomal dominant hereditary cancer syndrome, leading to increased risk of bilateral papillary type 1 kidney cancer. The disease locus is on chromosome 7q. The mutation responsible for this disorder involves : 

a) RET
b) MET
c) RAS
d) RAF

Answer : MET

Question 4 : Hereditary Leiomyomatosis and Renal Cell Carcinoma leads to highly aggressive papillary type 2 renal turmors. Which gene mutation is responsible for this syndrome : 

a) Fumarate hydratase
b) Fumarate dehydrogenase
c) Fumarate isocitrate dehydrogenase
d) None of the above

Answer : Fumarate Hydratase

Question 5 : Which of the following is associated with chromophobe RCC :

a) Birt-Hogg-Dube Syndrome
b) Tuberculosis sclerosis
c) HPRC syndrome
d) Von Hipple-Lindau disease

Answer : Birt-Hogg-Dube Syndrome

Question 6 : Which of the following is not a well established risk factor for RCC :

a) Smoking
b) Obesity
c) Alcohol
d) Hypertension

Answer :  alcohol

Question 7 : Deoxy-2[18F]fluoro-d-glucose positron emission tomography (PET) exhibits high sensitivity for the diagnosis of RCC and is therefore recommended for the evaluation of RCC:

a) True
b) False

Answer : False

Question 8 : What percentage of RCC have a familial basis :

a) 4
b) 10
c) 12-17
d) 25-30

Answer : 4% 

Question 9 : For incidentally detected small renal masses (SRMs) , or clinically localized renal cortical tumors up to 4 cm in size, which of the following is the standard of care :

a) Partial nephrectomy
b) Total nephrectomy
c) Active suveillance
d) Thermal ablation

Answer : partial nephrectomy

Question 10 : Which of the following characteristics is a case of RCC may fit an active surveillance approach rather than a surgical approach :

a) Lesions less than 2 cm in size
b) Complex cystic lesions (Bosniak 3/4)
c) In those where risk of death by surgery outweighs the benefits
d) All of the above

Answer : all of the above