Monoclonal Antibiotics Questions and Answers

Multiple Choice Questions and Answers on Monoclonal Antibiotics

Question 1 : The hybrid cells can be propagated

  1. in tissue culture
  2. as ascites in peritoneal cavity of mice
  3. both (1) and (2)
  4. none of these

Answer : 3

Question 2 : TC cells are important in controlling

  1. virus infections
  2. allergy
  3. autoimmunity
  4. all of these

Answer : 4

Question 3 : The antigen-specific lymphocytes can be immortalized by which of the following method?

  1. Transfection with tumor derived DNA
  2. Hybridization with a suitable lymphoid tumor cell
  3. Transformation following infection by Epstein-Barr virus (EB V)
  4. All of the above

Answer : 4

Question 4 : A cytokine that stimulates the activity of B and T cells is

  1. lymphotoxin
  2. interlukin-2
  3. interlukin-1
  4. all of these

Answer : 2

Question 5 : Which type of cell actually secrets antibodies?

  1. plasma cells
  2. T cells
  3. macrophages
  4. dendritic cells

Answer : 1

Question 6 : Which of the following is correct?

  1. rabbits do not make myelomas whereas mice are unable to synthesize antibodies
  2. rabbits do not make myelomas whereas mice are able to synthesize antibodies
  3. rabbits make myelomas whereas mice are unable to synthesize antibodies
  4. rabbits make myelomas whereas mice are able to synthesize antibodies

Answer : 1

Question 7 : The Ig locus is about

  1. 2/3rd of all hybridomas
  2. l/3rd of all hybridomas
  3. l/2nd of all hybridomas
  4. 1/4th of all hybridomas

Answer : 1

Question 8 : Small simple molecules are

  1. poor antigens
  2. rich antigens
  3. moderate antigens
  4. heterophilic antigens

Answer : 1

Question 9 : The EBV-hybridoma technique

  1. immortalizes the donor Bcells
  2. facilitates the proliferation of antigen specific B cells
  3. gives much higher hybridization frequencies
  4. all of the above

Answer : 4

Question 10 : Helper T cells assist in the functions of

  1. certain B cells
  2. certain T cells
  3. certain B cells and other T cells
  4. none of the above

Answer : 3

Question 11 : In immuno-inflammatory diseases such as hemolytic anaemia, eczema etc.

  1. T8 cells are greatly reduced
  2. T8 cells are greatly increased
  3. T4 cells are greatly reduced
  4. T4 cells are greatly increased

Answer : 1

Question 12 : Which of the following is incorrect?

  1. MAbs can be used to diagnose or treat diseases
  2. MAbs can be used in tumor scanning
  3. MAbs canbe used in cancer diagnosis
  4. MAbs can not be used in such non-infectious diseases as those of endocrine system

Answer : 4

Question 13 : In human B cells and T cells are matured in the

  1. bone marrow and thymus respectively
  2. lymph nodes and spleen respectively
  3. bursa and thymus respectively
  4. none of these

Answer : 1

Question 14 : An example of mosaic antigen is

  1. virus
  2. bacteria
  3. a hapten
  4. protein

Answer : 1

Question 15 : T cells are the source of

  1. interleukin
  2. interferon
  3. lymphotoxin
  4. all of these

Answer : 4

Question 16 : The primary B cell receptor is

  1. IgD
  2. IgG
  3. IgA
  4. IgE

Answer : 1

Question 17 : It is highly valued if the lymphocytes derived from the lymph node or tonsil tend to undergo fusion at

  1. high frequencies
  2. moderate frequencies
  3. low frequencies
  4. at no frequency

Answer : 1

Question 18 : The approach (s), which is/are currently followed to produce human monoclonal antibodies, is/are known as

  1. transformation of antigen specific B lymphocytes (EBV)
  2. hybridization of 6-thioguanine-resistant human plasmacytoma with immune human lymphocytes
  3. combination of EB Vand hybridoma techniques
  4. all of these

Answer : 4

Question 19 : Some cross reactions with monoclonal antibodies (MAbs) can occur. Unexpected cross reactions occur more frequently with

  1. Ig MAbs
  2. IgG
  3. IgA
  4. IgE

Answer : 1

Question 20 : Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the

  1. absence of human immune response against murine proteins (HAMA) response
  2. presence of HAMA response
  3. poor recognition of immunoglobulin, Ig constant regions
  4. all of the above

Answer : 1

Question 21 : In monoclonal antibody technology, tumor cells that can replicate endlessly are fused with mammalian cells that produce an antibody. The result of this cell fusion is a

  1. hybridoma
  2. myeloma
  3. natural killer cell
  4. lymphoblast

Answer : 1